Why we don't give peptide dosing, and who can
Plainly Graded does not publish doses for unapproved peptides because no human trial has established a tested dose for most of them, products sold online vary in what they contain, and instructions for unapproved drugs are where FDA enforcement draws the line.
We collect and compare information from public, cited sources. We cannot guarantee that it is complete, current or correct. This is not medical advice. Only a doctor can prescribe, and a doctor should confirm anything you read here before you act on it.
Based on public sources; we cannot guarantee it is correct. Not medical advice. A doctor should prescribe and confirm. Full disclaimer
Three reasons
- No established human dose. For most of these compounds the evidence is animal or cell work. An amount that worked in a rat is not a human dose.
- Product contents vary. Unapproved products have no required quality testing. FDA staff raised concerns about impurities, bacterial toxins and unreliable certificates in July 2026.
- It's the line FDA enforces. FDA's August 24, 2026 warning letters to five online sellers treated dosing aids and reconstitution calculators as evidence that products were meant for people.
Who can legally answer
- A prescribing clinician who knows your health history.
- For approved drugs, the FDA label, published on DailyMed.
- For research, ClinicalTrials.gov, which lists trials you may be able to join.
What to ask a prescriber
- Is there an approved treatment for what I want, tested in people?
- What is known and unknown about this compound's risks for someone like me?
- What should I watch for, and when should I stop and call you?
- Could it interact with anything I already take?
If you're already using a peptide
Keep the product label, and note when you started, how often you use it and any changes you notice. Tell any clinician you see, including in an emergency. You don't need to stop to ask for help.
- Swelling of the face, lips or throat, trouble breathing, chest pain, a racing heart or fainting. Call 911.
- Redness spreading from an injection site, warmth, pus or a fever. Get same-day care.
- Unsure what you took or whether a reaction is serious: Poison Control 1-800-222-1222 (free, 24 hours).
- Thoughts of harming yourself: call or text 988.
Questions
Can you tell me the dose that was used in a trial?
No. Trial doses were chosen for trial participants under medical supervision, and repeating them outside a trial is exactly the kind of instruction we decline to give. For approved drugs, the FDA label on DailyMed is the authoritative source, and a prescriber applies it to you.
Why not just publish what people report using?
Reported amounts describe what some people did, not what has been tested, and the contents of unregulated products vary. Publishing them would read as a recommendation.
Who can legally answer my dosing question?
A licensed prescriber who knows your history. For approved drugs, the FDA label. If you want to take part in research, ClinicalTrials.gov lists open trials.