--- title: "Wolverine stack: What's in It, Evidence and Legal Status" description: "Wolverine stack is a blend of BPC-157 and TB-500. No human trial has tested the combination. Evidence per ingredient, US status as of Oct 17, 2026, and…" canonical: https://plainlygraded.com/stacks/wolverine-stack/ last_updated: 2026-10-17 breadcrumb: "Home > Stacks and blends > Wolverine stack" publisher: Plainly Graded policy: "No dosing, no sourcing, no vendor links. Every claim cites a public source." --- > We collect and compare information from public, cited sources. We cannot guarantee that it is complete, current or correct. This is not medical advice. Only a doctor can prescribe, and a doctor should confirm anything you read here before you act on it. # Wolverine stack BPC-157 and TB-500 used together. Also sold as "BPC-157 + TB-500", "wolverine peptide", "wolverine blend" - FDA: not approved - WADA: contains 2 prohibited substances - No human trial of the blend STATUS AS OF 17 OCT 2026 **BPC-157 ·** FDA: not FDA-approved for any use · 503A: not on the 503A bulks list. FDA advisers recommended it on July 23, 2026; the vote is non-binding and no rule has been proposed · WADA: prohibited at all times under the 2026 WADA List (S0, non-approved substances) · [tracker entry](https://plainlygraded.com/regulatory/#bpc-157) **TB-500 ·** FDA: not FDA-approved for any use · 503A: not on the 503A bulks list. FDA advisers recommended it on July 23, 2026; the vote is non-binding and no rule has been proposed · WADA: prohibited at all times under the 2026 WADA List (S2.3: thymosin beta-4 and its derivatives, e.g. TB-500) · [tracker entry](https://plainlygraded.com/regulatory/#tb-500) **The short answer:** The Wolverine stack is an unapproved pairing of BPC-157 and TB-500 sold for injury recovery. As of October 17, 2026 no human trial has tested the pair, and both peptides are prohibited at all times under the 2026 WADA List. Written by [Maren Holt](https://plainlygraded.com/about/team/) 6 PUBLIC SOURCES · UPDATED 17 OCT 2026 · NO TIES TO SELLERS [How we source](https://plainlygraded.com/how-we-source/) ### Wolverine stack at a glance: evidence grade by ingredient | Ingredient | What it is | Grade | FDA | WADA 2026 | | --- | --- | --- | --- | --- | | [BPC-157](https://plainlygraded.com/peptides/bpc-157/) | Synthetic 15-amino-acid fragment of a gastric protein | **Evidence grade C** | Not approved | S0 prohibited | | [TB-500](https://plainlygraded.com/peptides/tb-500/) | Synthetic fragment of thymosin beta-4, a repair-related protein | **Evidence grade D** | Not approved | S2 prohibited | | **Wolverine stack (the blend)** | No published human or animal study of the pair | **Evidence grade U** | Not approved | Prohibited | A blend is graded as a blend: good evidence for an ingredient does not transfer to the mix. [How we grade](https://plainlygraded.com/evidence-grading/) ## What is in the Wolverine stack? The Wolverine stack is BPC-157 and TB-500 used together, named after the comic-book character who heals fast. The name is marketing, not a product standard. **Note:** We don't list amounts. Sellers and clinics combine these two in different proportions. [Why we don't publish doses or ratios](https://plainlygraded.com/why-we-dont-give-dosing/) ## What TB-500 on the label actually is TB-500 is a synthetic fragment linked to the LKKTETQ region of thymosin beta-4. The human trials people cite tested full-length thymosin beta-4 as eye drops, not the fragment sold as TB-500. ## Is the Wolverine stack legal, and will it fail a drug test? Neither peptide is FDA-approved, and neither can be lawfully compounded as of October 17, 2026. In sport, BPC-157 is prohibited under S0 and TB-500 under S2 of the 2026 WADA List, in and out of competition. Anti-doping rules work on strict liability: a positive test counts whatever the label said. The US military's Operation Supplement Safety also lists BPC-157 as prohibited. ### What sellers claim vs what has been shown | Claimed | Shown | | --- | --- | | Heals injuries faster than either alone | No study has tested the pair. Each has rodent or lab data only for injury repair.[1,3] | What we don't know - Whether the two interact: no study of the pair exists. - What is actually in products sold online. Why this page has no dosing We don't publish doses, schedules or mixing instructions for Wolverine stack or any unapproved peptide. No human dose has been established for most of these uses, so we list what to ask a licensed prescriber instead. [Here's why, and who can legally answer](https://plainlygraded.com/why-we-dont-give-dosing/) Get medical help now if you have - Swelling of the face, lips or throat, trouble breathing, chest pain, a racing heart or fainting. **Call 911.** - Redness spreading from an injection site, warmth, pus or a fever. Get same-day care. - Unsure what you took or whether a reaction is serious: **Poison Control 1-800-222-1222** (free, 24 hours). - Thoughts of harming yourself: call or text **988**. Who should be especially careful - **If you compete in tested sport or serve in the military.** Both peptides are prohibited at all times, and testing works on strict liability. - **If you have or have had cancer.** Both have a theoretical blood-vessel growth concern. - **If you are under 18.** Neither has been studied in young people. ### Compare next - [BPC-157](https://plainlygraded.com/peptides/bpc-157/) - [TB-500](https://plainlygraded.com/peptides/tb-500/) - [GLOW](https://plainlygraded.com/stacks/glow/) - [KLOW](https://plainlygraded.com/stacks/klow/) **Sources** 1. HSS Journal. [Emerging use of BPC-157 in orthopaedic sports medicine: a systematic review](https://pubmed.ncbi.nlm.nih.gov/40756949/), 2025. PMID 40756949. 2. Alternative Therapies in Health and Medicine. [Intra-articular injection of BPC 157 for multiple types of knee pain](https://pubmed.ncbi.nlm.nih.gov/34324435/), 2021. PMID 34324435. 3. ClinicalTrials.gov. Thymosin beta-4 (RGN-259) eye-drop trials in neurotrophic keratopathy and dry eye. 4. US Food and Drug Administration. Pharmacy Compounding Advisory Committee, meeting of July 23-24, 2026: briefing documents and vote record, 2026-07-23. 5. World Anti-Doping Agency. [2026 Prohibited List (sections S0 and S2)](https://www.wada-ama.org/en/prohibited-list), 2026-01-01. 6. Operation Supplement Safety (US Department of Defense). [BPC-157](https://www.opss.org/node/512764). **Changelog** 17 OCT 2026 Outline draft from brief 3. Full sections still to be written. Spotted an error? [Report it](https://plainlygraded.com/corrections/). We never change a page's updated date without changing its content. --- We collect and compare information from public, cited sources. We cannot guarantee that it is complete, current or correct. This is not medical advice. Only a doctor can prescribe, and a doctor should confirm anything you read here before you act on it. Canonical page: https://plainlygraded.com/stacks/wolverine-stack/