--- title: "PT-141: What It Is, Evidence and Legal Status (2026)" description: "PT-141: melanocortin peptide approved for low sexual desire in some women. FDA-approved use. US status as of Oct 17, 2026: approved, one use. No dosing,…" canonical: https://plainlygraded.com/peptides/pt-141/ last_updated: 2026-10-17 breadcrumb: "Home > Compounds > PT-141" publisher: Plainly Graded policy: "No dosing, no sourcing, no vendor links. Every claim cites a public source." --- > We collect and compare information from public, cited sources. We cannot guarantee that it is complete, current or correct. This is not medical advice. Only a doctor can prescribe, and a doctor should confirm anything you read here before you act on it. # PT-141 Also called "bremelanotide", "Vyleesi" - [FDA approved, one use](https://plainlygraded.com/regulatory/#pt-141) - [WADA: being checked](https://plainlygraded.com/regulatory/#pt-141) STATUS AS OF 17 OCT 2026 FDA: approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women only · WADA: wADA status not yet checked against the List · [tracker entry](https://plainlygraded.com/regulatory/#pt-141) **The short answer:** PT-141 is the research name for bremelanotide, a melanocortin-receptor peptide. As of October 17, 2026 it is FDA-approved as Vyleesi for one use: low sexual desire in premenopausal women. Products sold online as PT-141 for other uses are not the approved drug. Written by [Maren Holt](https://plainlygraded.com/about/team/) 1 PUBLIC SOURCES · UPDATED 17 OCT 2026 · NO TIES TO SELLERS [How we source](https://plainlygraded.com/how-we-source/) ## What is PT-141? Melanocortin peptide approved for low sexual desire in some women. Full section still to be written. ## What is PT-141 claimed to do, and what does the evidence show? **Overall grade** - Approved **Strongest evidence** Phase 3 trials | Use | Claimed | Shown | Grade | | --- | --- | --- | --- | | Low sexual desire in premenopausal women | Raises sexual desire | Approved by the FDA for this use only.[1] | Approved | ## What are the known risks and side effects of PT-141? The approved label lists the known side effects and warnings. We link to it rather than restate it. Who should be especially careful - **People who are pregnant, trying to get pregnant or breastfeeding.** There is no human data in pregnancy. - **Anyone under 18.** It has not been studied in young people. - **Tested athletes and service members.** Check with USADA or your service's rules first. A positive test counts whatever the label said. - **People taking prescription medicines.** Interactions have not been studied. Bring the product label to your clinician. Get medical help now if you have - Swelling of the face, lips or throat, trouble breathing, chest pain, a racing heart or fainting. **Call 911.** - Redness spreading from an injection site, warmth, pus or a fever. Get same-day care. - Unsure what you took or whether a reaction is serious: **Poison Control 1-800-222-1222** (free, 24 hours). - Thoughts of harming yourself: call or text **988**. ## Is PT-141 legal? Approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women only.[1] Every status change for PT-141 is logged with its date and source in the [regulatory tracker entry for PT-141](https://plainlygraded.com/regulatory/#pt-141). ## Is PT-141 banned in sport? WADA status not yet checked against the List. Anti-doping rules work on strict liability: a positive test counts whatever the label said. ## What don't we know about PT-141? Still unknown Still being written. Why this page has no dosing We don't publish doses, schedules or mixing instructions for PT-141 or any unapproved peptide. No human dose has been established for most of these uses, so we list what to ask a licensed prescriber instead. [Here's why, and who can legally answer](https://plainlygraded.com/why-we-dont-give-dosing/) ## What should you tell your doctor if you're using PT-141? Tell them exactly what you took, for how long, and where it came from, and bring the label. These questions can help the conversation: - Is there an approved treatment for my goal that has been tested in people? - What should I watch for, and which symptoms mean I should stop and call you? - Could it interact with the medicines I already take? **Sources** 1. DailyMed / US Food and Drug Administration. Vyleesi (bremelanotide) prescribing information. **Changelog** 17 OCT 2026 Draft. Statuses read from the regulatory record dated 2026-10-17. Spotted an error? [Report it](https://plainlygraded.com/corrections/). We never change a page's updated date without changing its content. --- We collect and compare information from public, cited sources. We cannot guarantee that it is complete, current or correct. This is not medical advice. Only a doctor can prescribe, and a doctor should confirm anything you read here before you act on it. Canonical page: https://plainlygraded.com/peptides/pt-141/